Endocrine Abstracts

Introduction: Gardner syndrome (GS) have very different extraintestinal manifestations such as include osteomas and thyroid cancers. Thyroid carcinomas associated with familial adenomatozis polyposis coli (FAP), are typically bilateral and multifocal. Our case presenting that GS included Graves’ disease (GD) and aggressive varyant of PTC.Case report: A 43-year-old men admitted to our out patient clinic for thyrotoxicosis investigation. He was compla...

Introduction: Polycystic ovary syndrome (PCOS) is widely diagnosed among young women in reproductive age. Vitamin D deficiency has been known as a common problem in all ages and also in a recent study which performed in a small study groups, reported that it may accompany with hyperandrogenism. The aim of our study is to evaluate serum 25(OH)D3 levels in PCOS patients compared with healthy control and relation to androgen levels.Methods: Forty...

Background and aims: We aimed to establish the frequency of vitamin D deficiency and analyse its association with gestational diabetes (GDM).Material and methods: In this descriptive, case control and cross sectional study, pregnant women were screened at 24–28 weeks of pregnancy using a 75 g, 2 h oral glucose tolerance test. Fourthy-six GDM diagnosed (case, group 1) and 43 healthy pregnants (control, group 2) were recruited. Plasma 25-hydroxyvitami...

Background and aims: This study was done to predict renal impairment in type 2 diabetic patients with normo or microalbuminuria by detection of serum cystatin C, serum and urinary TGF-β levels.Material and methods: Seventy-eight patients were categorized into four groups depending on urinary albumin excretion and eGFR: eGFR <60 ml/min per 1.73 m2 with normoalbuminuria in group 1; eGFR was <60 or >60 ml/min per 1.73 m2</su...

Introduction: To date, several mutations have been identified as the underlying cause of hypogonadotropic hypogonadism. However, they account for a small minority of cases, suggesting that other genes play a significant role in the pathogenesis. The aim of the present study was to examine the prevalence of KAL1, GnRH1, GnRHR, PROK2 and PROKR2 mutations. Because it has several advantages over traditional screening methods, multiplex ligation dependent probe amplification (MLPA)...

In prolactinomas, today first choice of treatment is medical treatment with dopamine agonists. Cavernous sinus invasion is not uncommon in prolactinomas and stands out as a blocking factor for surgical removal of the tumor fully. In our study, the presence of cavernous sinus invasion was to investigate the effect on the results of surgical and medical treatment in prolactinomas.Eighty-seven patients followed up with a diagnosis of prolactinoma were inclu...

Prolactinomas are more common tumors by 60% among the hypophysis adenomas. These are often benign, but may present differences in terms of tumor size and treatment responses. Aim of this study was investigate the relationship of serum prolactin levels with tumor size and invasiveness in the prolactinomas.113 patients with the diagnosis of prolactinoma were included to study. Pretreatment plasma levels of prolactin in the time of diagnosis and sella MR im...

Background and aim: Subclinical hypothyrodism (SH) appears to be associated with mood and changes. The aims of this study were: i) to determine whether depression is more common in SH, and ii) to investigate the effects of L-thyroxine (LT4) therapy on depressive symptoms.Methods: 31 patients with SH and 36 age amd BMI matched healthy controls were included. Beck and Hamilton scales were used to evaluate depression...

Introduction: Prolactinomas, although considered benign, show various intensity of aggressiveness. Some remain constant for whole life period while some harbour initially with invasive extension to the parasellar area. We aimed to evaluate the effect of age and gender on the invasiveness of prolactinomas.Material-methods: One hundred and thirteen patients with prolactinoma were retrospectively evaluated. Magnetic resonance images were carefully examined ...

Introduction: Fine-needle aspiration (FNA) biopsy of thyroid nodules is minimally invasive and safe. The clinical importance of the thyroid nodule evaluation is primarily related to the need to exclude thyroid cancer. We aimed to investigate the relationship between preoperative FNA cytology and results of thyroidectomy in this study.Materials and Methods: Histopathologic examination reports of 302 patients undergoing thyroidectomy and preoperative FNA c...